Publications
*Corresponding author
51. Tsai C-H, Chuang Y-M, Li X, Yu Y-R, Tzeng S-F, Teoh ST, Lindblad KE, Matteo MD, Cheng W-C, Hsueh P-C, Kao K-C, Imrichova H, Duan L, Gallart-Ayala H, Hsiao P-W, Mazzone M, Ivanesevic J, Liu X, de Visser KE, Lujambio A, Lunt SY, Kaech SM, Ho P-C. Immunoediting instructs tumor metabolic reprogramming to support immune evasion. Cell Metabolism, 35 (1), 118-133.e7; 2023.
50. Medeiros HCD and Lunt SY*. The Warburg effect: Saturation of mitochondrial NADH shuttles triggers aerobic lactate fermentation. Molecular Cell, 82, 3119–3121; 2022.
49. Broadwater D, Medeiros HCD, Bates M, Roshanzadeh A, Teoh ST, Ogrodzinski MP, Borhan B, Lunt RR*, Lunt SY*. Counterion Tuning of Near-Infrared Organic Salts Dictates Phototoxicity to Inhibit Tumor Growth. ACS Applied Materials & Interfaces, 14, 48, 53511–53522; 2022.
48. Rossi M, Altea-Manzano P, Demicco M, Doglioni G, Bornes L, Fukano M, Vandekeere A, Cuadros AM, Fernández-García J, Riera-Domingo C, Jauset C, Planque M, Alkan HF, Nittner D, Zuo D, Broadfield LA, Parik S, Pane AA, Rizzollo F, Rinaldi G, Zhang T, Teoh ST, Aurora AB, Karras P, Vermeire I, Broekaert D, Elsen JV, Knott MML, Orth MF, Demeyer S, Eelen G, Dobrolecki LE, Bassez A, Brussel TV, Sotlar K, Lewis MT, Bartsch H, Wuhrer M, Veelen P van, Carmeliet P, Cools J, Morrison SJ, Marine J-C, Lambrechts D, Mazzone M, Hannon GJ, Lunt SY, Grünewald TGP, Park M, Rheenen J van and Fendt S-M*. PHGDH heterogeneity potentiates cancer cell dissemination and metastasis. Nature, 605, 747–753; 2022.
47. Wenes M, Jaccard A, Wyss T, Maldonado-Pérez N, Teoh ST, Lepez A, Renaud F, Franco F, Waridel P, Yacoub Maroun C, Tschumi B, Dumauthioz N, Zhang L, Donda A, Martín F, Migliorini D, Lunt SY, Ho PC, Romero P*. The mitochondrial pyruvate carrier regulates memory T cell differentiation and antitumor function. Cell Metabolism, 34(5):731-746; 2022.
46. Medeiros HCD, Yang C, Herrera CK, Broadwater D, Ensink E, Bates M, Lunt RR*, Lunt SY*. Phosphorescent Metal Halide Nanoclusters for Tunable Photodynamic Therapy. Chemistry – A European Journal, e202202881; 2022.
45. Bates M, Lunt SY, and Lunt RR. Impact of charge character on anionic cyanine-based organic salt photovoltaics. Journal of Applied Physics, 132, 085501; 2022.
44. Teoh ST, Leimanis-Laurens ML, Comstock SS, Winters JW, Vandenbosch NL, Prokop JW, Bachmann AS, Lunt SY* and Rajasekaran S*. Combined plasma and urinary metabolomics uncover metabolic perturbations associated with severe respiratory syncytial viral infection and future development of asthma in infant patients. Metabolites; 12, 178; 2022. *Co-corresponding authors
43. Russell MM, Leimanis-Laurens ML, Bu S, Kinney GA, Teoh ST, McGee RL, Ferguson K, Winters JW, Lunt SY, Prokop JW, Rajasekaran S and Comstock SS. Loss of Health Promoting Bacteria in the Gastrointestinal Microbiome of PICU Infants with Bronchiolitis: A Single-Center Feasibility Study. Children; 9, 114; 2022.
42. Ogrodzinski MP, Teoh ST & Lunt SY*. Targeting subtype-specific metabolic preferences in nucleotide biosynthesis inhibits tumor growth in a breast cancer model. Cancer Research, 2021.
41. Broadwater D, Medeiros HCD, Lunt RR* & Lunt SY*. Current Advances in Photoactive Agents for Cancer Imaging and Therapy. Annual Review of Biomedical Engineering; 23: 29-60; 2021.
40. Rinaldi G, Pranzini E, Van Elsen J, Broekaert D, Funk CM, Planque M, Doglioni G, Altea-Manzano P, Rossi M, Geldhof V, Teoh ST, Ross C, Hunter KW, Lunt SY, Grünewald TGP & Fendt S-M. In Vivo Evidence for Serine Biosynthesis-Defined Sensitivity of Lung Metastasis, but Not of Primary Breast Tumors, to mTORC1 Inhibition. Molecular Cell, 2021.
39. Panwalkar P, Tamrazi B, Dang D, Chung C, Sweha S, Natarajan SK, Pun M, Bayliss J, Ogrodzinski MP, Pratt D, Mullan B, Hawes D, Yang F, Lu C, Sabari BR, Achreja A, Heon J, Animasahun O, Cieslik M, Dunham C, Yip S, Hukin J, Phillips JJ, Bornhorst M, Griesinger AM, Donson AM, Foreman NK, Garton HJL, Heth J, Muraszko K, Nazarian J, Koschmann C, Jiang L, Filbin MG, Nagrath D, Kool M, Korshunov A, Pfister SM, Gilbertson RJ, Allis CD, Chinnaiyan AM, Lunt SY, Blüml S, Judkins AR, Venneti S. Targeting integrated epigenetic and metabolic pathways in lethal childhood PFA ependymomas. Science Translational Medicine; 13: 614; 2021.
38. Lensmire JM, Wischer MR, Sosinski LM, Ensink E, Dodson JP, Shook JC, Delekta PC, Cooper CC, Havlichek Jr. D, Mulks MH, Lunt SY, Ravi J, Hammer ND. The glutathione import system satisfies the Staphylococcus aureus nutrient sulfur requirement and promotes interspecies competition. bioRxiv 2021.10.26.465763.
37. Gupta R, Leimanis ML, Adams M, Bachmann AS, Uhl KL, Bupp CP, Hartog NL, Kort EJ, Olivero R, Comstock SS, Sanfilippo DJ, Lunt SY, Prokop JW*, and Rajasekaran S. Balancing Precision vs. Cohort Transcriptomic Analysis of Acute and Recovery Phase of Viral Bronchiolitis. American Journal of Physiology-Lung Cellular and Molecular Physiology, 320(6): L1147-L1157; 2021.
36. Teoh ST, Ogrodzinski MP & Lunt SY*. UDP-Glucose 6-Dehydrogenase Knockout Impairs Migration and Decreases in vivo Metastatic Ability of Breast Cancer Cells. Cancer Letters; 492: 21-30; 2020.
35. Ogrodzinski MP, Teoh ST & Lunt SY*. Metabolomic profiling of mouse mammary tumor derived cell lines reveals targeted therapy options for cancer subtypes. Cellular Oncology; 2020.
34. Fendt S-M & Lunt SY*. Dynamic ROS Regulation by TIGAR: Balancing Anti-cancer and Pro-metastasis Effects. Cancer Cell; 37: 141-142; 2020.
33. Mukerjee S, Gonzalez-Reymundez A, Lunt SY & Vazquez AI. DNA Methylation and Gene Expression with Clinical Covariates Explain Variation in Aggressiveness and Survival of Pancreatic Cancer Patients. Cancer Investigation; 2020.
32. Yu L, Teoh ST, Ensink E, Ogrodzinski MP, Yang C, Vazquez AI & Lunt SY*. Cysteine catabolism and the serine biosynthesis pathway support pyruvate production during pyruvate kinase knockdown in pancreatic cancer cells. Cancer & Metabolism; 7: 13; 2019.
31. Brinker A, Vivian C, Beadnell T, Koestler D, Teoh ST, Lunt SY & Welch D. Mitochondrial haplotype of the host stromal microenvironment alters metastasis in a non-cell autonomous manner. Cancer Research; 2019.
30. Broadwater D†, Bates M†, Jayaram M, Young M, He J, Raithel AL, Hamann TW, Zhang W, Borhan B, Lunt RR* & Lunt SY*. Modulating cellular cytotoxicity and phototoxicity of fluorescent organic salts through
counterion pairing. Scientific Reports; 9: 15288; 2019.
†Co-first authors.
*Co-corresponding authors
29. Kariagina A, Lunt SY* & McCormick JJ*. Genomic and Metabolomic Analysis of Step-Wise Malignant Transformation in Human Skin
Fibroblasts. Carcinogenesis; 1-10; 2019.
*Co-corresponding authors
28. Rennhack J, To B, Swiatnicki M, Dulak C, Ogrodzinski MP, Zhang Y, Li C, Bylett E, Ross C, Szczepanek K, Hanrahan W, Jayatissa M, Lunt SY, Hunter KW, and Andrechek ER. Integrated analyses of murine breast cancer models reveal critical parallels with human disease. Nature Communications; 10: 3261; 2019.
27. Fendt S-M & Lunt SY (editors). Metabolic Signaling: Methods and Protocols. Methods in Molecular Biology; 1862, Springer Science+Business Media, LLC, part of Springer Nature,Humana Press, New York, NY; 2019.
26. Ogrodzinski MP, Teoh ST, Yu L, Broadwater D, Ensink E, Lunt SY*. Measuring the Nutrient Metabolism of Adherent Cells in Culture. Methods in Molecular Biology; 1862: 37-52; 2019.
25. Kuttipillai PS, Yang C, Chen P, Wang L, Bates M, Lunt SY; Lunt RR. Enhanced Electroluminescence Efficiency in Metal Halide Nanocluster Based Light Emitting Diodes through Apical Halide Exchange. ACS Applied Energy Materials; 1: 3587-3592; 2018.
24. Teoh ST, Ogrodzinski MP, Ross C, Hunter KW & Lunt SY*. Sialic Acid Metabolism: A Key Player in Breast Cancer Metastasis Revealed by Metabolomics. Frontiers in Oncology; 8: 1-15; 2018.
23. Lunt SY & Fendt S-M. Metabolism - A cornerstone of cancer initiation, progression, immune evasion and treatment response. Current Opinion in Systems Biology; 8: 67-72; 2018.
22. Hodeib M†, Ogrodzinski MP†, Vergnes L, Reue K, Karlan BY, Lunt SY & Aspuria PJP. Metformin Induces Distinct Bioenergetic and Metabolic Profiles in Sensitive Versus Resistant High Grade Serous Ovarian Cancer and Normal Fallopian Tube Secretory Epithelial Cells. Oncotarget; 9: 4044-4060; 2018. †Co-first authors.
21. Liu D, Wang Q, Traverse CJ, Yang C, Young M, Kuttipillai PS, Lunt SY, Hamann TW & Lunt RR. Impact of Ultrathin C60 on Perovskite Photovoltaic Devices. ACS Nano; 2017.
20. Teoh ST & Lunt SY*. Metabolism in Cancer Metastasis: Bioenergetics, Biosynthesis and Beyond. Wiley Interdisciplinary Reviews: Systems Biology and Medicine; e1406:1-27; 2017.
[Highlighted in Advanced Science News.]
19. Ogrodzinski MP, Bernard JJ & Lunt SY*. Deciphering Metabolic Rewiring in Breast Cancer Subtypes. Translational Research; 189: 105-122; 2017.
18. Chakraborty D, Benham V, Bullard B, Kearney T, Hsia HC, Gibbon D, Demireva EY, Lunt SY & Bernard JJ. Fibroblast growth factor receptor is a mechanistic link between visceral adiposity and cancer. Oncogene; 1-12; 2017.
17. Traverse CJ, Young M, Suddard-Bangsund J, Patrick T, Bates M, Chen P, Wingate B, Lunt SY, Anctil A & Lunt RR. Anions for Near-Infrared Selective Organic Salt Photovoltaics. Scientific Reports; 7: 1-8; 2017.
16. González-Reymúndez A, de los Campos G, Gutiérrez L, Lunt SY & Vazquez AI. Prediction of Years of Life after Diagnosis of Breast Cancer Using Omics and Omic-by-Treatment Interactions. European Journal of Human Genetics; 25 (5): 538–544; 2017.
15. Nault R, Fader KA, Ammendolia DA, Dornbos P, Potter D, Sharratt B, Kumagai K, Harkema JR, Lunt SY, Matthews J & Zacharewski T. Dose-dependent metabolic reprogramming and differential gene expression in TCDD-elicited hepatic fibrosis. Toxicological Sciences; 154 (2): 253-266; 2016.
14. Young M, Suddard-Bangsund JD, Patrick TJ, Pajares N, Lunt SY & Lunt RR: Organic Heptamethine Salts for Photovoltaics and Detectors with Near-Infrared Photoresponse up to 1600 nm. Advanced Optical Materials; 4 (7):1028-1033; 2016.
13. Nault R, Fader KA, Kirby MP, Ahmed S, Matthews J, Jones AD, Lunt SY & Zacharewski TR: Pyruvate kinase isoform switching and hepatic metabolic reprogramming by the environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Toxicological Sciences; 149 (2): 358-371; 2016.
12. Schoors S, Bruning U, Missiaen R, Queiroz KC, Borgers G, Elia I, Zecchin A, Cantelmo AR, Christen S, Goveia J, Heggermont W, Goddé L, Vinckier S, Veldhoven PP, Eelen G, Schoonjans L, Gerhardt H, Dewerchin M, Baes M, Bock KD, Ghesquière B, Lunt SY, Fendt S-M & Carmeliet P: Fatty acid synthesis is essential for dNTP synthesis in endothelial cells. Nature; 520: 192-197; 2015.
11. Buescher, JM, Antoniewicz MR, Boros LG, Burgess SC, Brunengraber H, Clish CB, DeBerardinis RJ, Feron O, Frezza C, Ghesquiere B, Gottlieb E, Hiller K, Jones RG, Kamphorst JJ, Kibbey RG, Kimmelman AC, Locasale JW, Lunt SY, Maddocks OD, Malloy C, Metallo CM, Meuillet EJ, Munger J, Noh K, Rabinowitz JD, Ralser M, Sauer U, Stephanopoulos G, St-Pierre J, Tennant DA, Wittmann C, Vander Heiden MG, Vazquez A, Vousden K, Young JD, Zamboni N & Fendt S-M: A roadmap for interpreting C metabolite labeling patterns from cells. Current opinion in biotechnology; 34C: 189-201; 2015.
10. Lunt SY, Muralidhar V, Hosios AM, Israelsen WJ, Gui DY, Newhouse L, Ogrodzinski M, Hecht V, Xu K, Marín Acevedo PN, Hollern DP, Bellinger G, Dayton TL, Christen S, Elia I, Dinh AT, Stephanopoulos G, Manalis SR, Yaffe MB, Andrechek ER, Fendt S-M & Vander Heiden MG: Pyruvate kinase isoform expression alters nucleotide synthesis to impact cell proliferation. Molecular Cell; 57(1):95-107; 2015.
9. Aspuria PJP, Lunt SY, Väremo L, Vergnes L, Gozo M, Beach J, Salumbides B, Reue K, Morin-Kensicki E, Nielsen J, Karlan BY & Orsulic S: Succinate dehydrogenase inhibition leads to epithelial-mesenchymal transition in mouse ovarian cancer cells. Cancer & Metabolism; 2: 21; 2014.
8. Martin ES, Belmont PJ, Sinnamon MJ, Richard LG, Yuan J, Coffee EM, Roper J, Lee L, Heidari P, Lunt SY, Goel G, Ji X, Xie Z, Xie T, Lamb J, Weinrich SL, VanArsdale T, Bronson RT, Xavier RJ, Vander Heiden MG, Kan JL, Mahmood U & Hung KE: Development of a GEMM-Derived Orthotopic Transplant (GDOT) Platform for Drug Discovery and Validation. Clinical Cancer Research; 19: 2929-2940; 2013.
7. Anastasiou D, Yu Y, Israelsen WJ, Jiang JK, Boxer MB, Hong BS, Tempel W, Dimov S, Shen M, Jha A, Yang H, Mattaini KR, Metallo CM, Fiske BP, Courtney KD, Malstrom S, Khan TM, Kung C, Skoumbourdis AP, Veith H, Southall N, Walsh MJ, Brimacombe KR, Leister W, Lunt SY, Johnson ZR, Yen KE, Kunii K, Davidson SM, Christofk HR, Austin CP, Inglese J, Harris MH, Asara JM, Stephanopoulos G, Salituro FG, Jin S, Dang L, Auld DS, Park HW, Cantley LC, Thomas CJ & Vander Heiden MG: Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis. Nature Chemical Biology; 10: 839-847; 2012.
6. Vander Heiden MG, Lunt SY, Dayton TL, Fiske BP, Israelsen WJ, Mattaini KR, Vokes NI, Stephanopoulos G, Cantley LC, Metallo CM & Locasale JW: Metabolic pathway alterations that support cell proliferation. Cold Spring Harb Symp Quant Biol; 76: 325-334; 2011.
5. Lunt SY & Vander Heiden MG: Aerobic glycolysis: meeting the metabolic requirements of cell proliferation. Annual Review of Cell and Developmental Biology; 27: 441-464; 2011.
Published under former name (Kwon YK):
4. Kwon YK, Higgins MB & Rabinowitz JD: Antifolate-induced depletion of intracellular glycine and purines inhibits thymineless death in E. coli. ACS Chemical Biology; 5: 787-795; 2010.
3. Kwon YK, Lu W, Melamud E, Khanam N, Bognar A & Rabinowitz JD: A domino effect in antifolate drug action in Escherichia coli. Nature Chemical Biology; 4: 602-608; 2008.
[Featured on cover]
2. Lu W, Kwon YK & Rabinowitz JD: Isotope ratio-based profiling of microbial folates. Journal of the American Society for Mass Spectrometry; 18: 898-909; 2007.
1. Moe OA, Patton WA, Kwon YK & Kedney, MG. Ladder sequencing of a peptide using MALDI-TOF mass spectrometry. Chemical Educator; 9: 272-275; 2004.
PubMed publication search.